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Story at-a-glance
The U.S. Health and Human Services' Operation Warp Speed has pledged to deliver 300 million doses of a COVID-19 vaccine by 2021,1 if not sooner.2 However, developing a safe and effective vaccine normally takes years and begins with animal studies. The COVID-19 vaccines are all being rushed straight into human clinical tests, forgoing lengthy animal trials altogether.
Such fast-tracked vaccines pose unknown risks, which are further magnified since governments are granting COVID-19 vaccine makers immunity from liability for all vaccine injuries and deaths that occur after the vaccines are recommended (or mandated) by public health officials.3
At the end of July 2020, AstraZeneca announced4 most countries it expects to supply with COVID-19 vaccine will grant the pharmaceutical company complete liability protection if people are harmed.
In the U.S., vaccine makers already have something of a "free pass" when it comes to vaccine injury liability and lawsuits through the National Childhood Vaccine Injury Act of 19865 and the Public Readiness and Emergency Preparedness (PREP) Act, passed in 2005.6
The main concern is that the combination of COVID-19 vaccines being fast-tracked to market at "warp speed" with minimal testing, together with blanket liability protection against vaccine injuries could be a public health nightmare in the making.

Problems With Moderna’s Vaccine Are Becoming Apparent

Early warning signs that something might be amiss have already started emerging. As detailed in “Gates Tries to Justify Side Effects of Fast-Tracked Vaccine,” results7 from Moderna’s Phase 1 human trial revealed 100% of volunteers in the high-dose group suffered systemic side effects. Side effects included fatigue, chills, headache and myalgia (muscle pain); 21% suffered “one or more severe events.”
According to Bill Gates, those side effects are largely due to the high dosages Moderna had to use in order to achieve desired antibody levels. But, if high dosages are required to create a robust-enough immune response, and higher dosages also cause systemic side effects in nearly all people, just how safe will this vaccination campaign be?
In the 20 years that vaccine makers have tried to develop a coronavirus vaccine, efforts have failed due to dangerous, many times lethal, side effects.
In July, it was reported8 that the 100-mcg dose vaccine — despite its 100% side effect ratio after the second dose — would proceed to Phase 3 trial assessment. In a May 26, 2020, article9 in STAT news, Ian Haydon, one of the Phase 1 study participants who suffered severe side effects requiring hospitalization, stated that while he recovered, the inoculation left him feeling “as sick as he’d ever felt.” As noted by Robert F. Kennedy Jr.:10
“Three of the 15 human guinea pigs in the high dose cohort (250 mcg) suffered a ‘serious adverse event’ within 43 days of receiving Moderna’s jab. Moderna … acknowledged that three volunteers developed Grade 3 systemic events defined by the FDA as ‘Preventing daily activity and requiring medical intervention.’
Moderna allowed only exceptionally healthy volunteers to participate in the study. A vaccine with those reaction rates could cause grave injuries in 1.5 billion humans if administered to ‘every person on earth.’ That is the threshold that Gates has established for ending the global lockdown.
Moderna did not explain why it reported positive antibody tests for only eight participants. These outcomes are particularly disappointing because the most hazardous hurdle for the inoculation is still ahead; challenging participants with wild COVID infection.
Past attempts at developing COVID vaccines have always faltered at this stage as both humans and animals achieved robust antibody response then sickened and died when exposed to the wild virus.”

Moderna Patent Problems

Other signs of trouble include reports that Moderna has no legal rights to a key patent for its vaccine delivery system, and that company executives are now dumping their stocks. There are also questions emerging as to whether Moderna had some sort of foreknowledge that a coronavirus pandemic might be in the making.
In the video above, independent journalist Ben Swann reports Moderna filed a patent amendment in March 2019, nine months before the COVID-19 pandemic started, stating there was a need for this vaccine technology out of concern for “reemergence or deliberate release of the SARS coronavirus.”
The amendment was done to a patent application that had been repeatedly rejected since its initial filing in 2015. The March 2019 amendment stressed the importance of obtaining this patent due to concerns of a beta coronavirus pandemic. Of all the viruses in the world, why would they suspect a coronavirus pandemic?
In December 2019, the U.S. Patent Office issued a final rejection of Moderna’s patent application, yet when the COVID-19 pandemic broke out in early 2020, Moderna was among the first to state they had the ability to address the problem.
It wasn’t until May 2020, months after it had already entered into partnership with the U.S. National Institutes of Health to develop the vaccine, that Moderna was finally issued the patent for it. And, even then, a key patent for the technology already belonged to another company. The NIH also holds many patents on the core mRNA technology used by Moderna.
David E. Martin, Ph.D., a national intelligence analyst featured in Swann’s video report, points out that even though Moderna “very clearly did not have the legal right, and they did not have the contractual rights, they didn’t have the licensing rights” required to enter into a federal contract, they were still somehow pushed to the front of the line by the NIH and Dr. Anthony Fauci.
“This is a situation in which the horse that was being bet on, Moderna, is actually not even qualified to run in the race,” Martin says.
Martin goes on to explain how both Moderna and the NIH are essentially engaged in patent infringement, as a core part of the technology — the lipid nanoparticle technology that is part of the vaccine delivery system — belongs to another company.
Moderna sought to invalidate the patent owned by Arbutus Biopharma, but lost the challenge at the end of July 2020.11,12 As a result, Arbutus might be able to make a royalty claim in the vaccine, and news of the failed patent challenge caused Moderna’s stock to drop by 9.5%.13

Moderna Executives Have Raked in Millions on Dumped Stocks

As reported by NPR14 September 4, 2020, executives at Moderna have also cashed in stock options, raking in tens of millions of dollars of personal profit in the process. Considering the patent problems now emerging and the lingering safety and efficacy questions, this move has raised significant concerns among financial experts:
“’On a scale of one to 10, one being less concerned and 10 being the most concerned,’ said Daniel Taylor, an associate professor of accounting at the Wharton School, ‘this is an 11.’ Taylor said Moderna's stock-selling practices appear well outside the norm, and raise questions about the company's internal controls to prevent insider trading.
Since January, CEO Stéphane Bancel has sold roughly $40 million worth of Moderna stock held by himself or associated investment funds; Chief Medical Officer Tal Zaks has sold around $60 million; and President Stephen Hoge has sold more than $10 million …
Advocates have questioned whether it's appropriate for executives to privately profit before bringing the vaccine to market, especially when American taxpayers have committed roughly $2.5 billion to the company's vaccine development and manufacture.”
Importantly, NPR discovered that several of the executives appear to have made “questionable modifications to stock sale plans” shortly before key announcements were made about the vaccine — in some cases just a single day ahead of the announcements.
In order to be legal, prescheduled stock sale plans must be made at a time when no confidential inside information is available that may influence their sales decisions, so the timing of their modifications appears suspicious.
What’s more, as a general rule, corporate best practices call for leadership to maintain stock in the company to ensure they have sufficient incentive to improve company performance. Two Moderna executives, however, have sold all of their stock holdings, and its general counsel has sold “nearly all” of hers, NPR reports.15

What Do Moderna Execs Know That We Don’t?

Why would executives unload their stocks before the vaccine is even launched? Do they suspect or know something has, or is about to go awry? As of right now, there’s no evidence whatsoever that the company’s novel vaccine will actually work, let alone be safe. According to NPR:16
"Friday, March 13, three Moderna executives adopted new 10b5-1 plans, according to records reviewed by NPR: Zaks, Chief Technical Operations and Quality Officer Juan Andres, and then-Chief Financial Officer Lorence H. Kim …
On Monday, March 16 — one business day later — the company announced that it had given a participant the first dose of their vaccine as part of its phase 1 trial. The stock ended that day up 24% compared to the previous day's close …
’Every company and individual is entitled to the presumption of innocence. That said, from the public's perspective, this trading behavior looks very problematic,’ said Taylor … who first pointed out the timing of these changes to NPR.
‘If I put on my SEC enforcement hat, I would certainly be asking, 'What caused you to change the plan on a Friday?'’ said Kurt Wolfe, who works as a defense attorney in securities cases for the firm Troutman Pepper. ‘I don't think it's a good fact pattern.’"

Coronavirus Vaccines Have Never Been Successfully Made

As I’ve discussed in several previous articles, COVID-19 vaccine manufacturers have several hurdles to overcome, as coronavirus vaccine development has been notoriously challenging. In the 20 years that vaccine makers have tried to develop a coronavirus vaccine, efforts have failed due to dangerous, many times lethal, side effects.
Adding to the problem is that many of them are relying on novel mRNA technology that has never been used in vaccines before.17 Making matters even worse, the vaccines are not safety tested against inert placebo, as is the gold standard for drug safety research. Oxford University’s mRNA vaccine, ChAdOx1 nCoV-19, for example, is being compared to a meningitis vaccine.18
As discussed in “Dangerous Placebos Used in Medical Trials,” using an active substance such as another vaccine destroys any hope of a valid safety study. This is just one way in which vaccine makers cheat in their safety studies to minimize the appearance of adverse effects.
In the case of a COVID-19 vaccine, establishing safety is of utmost importance, as previous coronavirus vaccines have caused paradoxical immune enhancement — a situation in which the vaccine actually makes you more susceptible to severe illness and death once you’re infected with the actual virus.
Kennedy explained this in my interview with him, featured in “Robert F. Kennedy Jr. Explains Well-Known Hazards of Coronavirus Vaccines.”
Aside from the possibility of a paradoxical immune response, mRNA vaccines may in and of themselves be problematic. According to researchers at the University of Pennsylvania and Duke University:19,20
“mRNA vaccines have potential safety issues, including local and systemic inflammation and stimulation of auto-reactive antibodies and autoimmunity, as well as development of edema (swelling) and blood clots.”

AstraZeneca Stopped Its Vaccine Trial Due to Side Effects

September 8, 2020, STAT News reported21 that AstraZeneca has temporarily halted its Phase 3 vaccine trials due to “a suspected serious and unexpected adverse reaction” in a British participant.
The company did not divulge the nature of the adverse reaction. The New York Times claims22 “a person familiar with the situation, and who spoke on the condition of anonymity” said the individual ”had been found to have transverse myelitis, an inflammatory syndrome that affects the spinal cord and is often sparked by viral infections.”
AstraZeneca, in collaboration with the University of Oxford, is conducting Phase 2/3 trials for their mRNA COVID-19 vaccine (ChAdOx1 nCoV-19, a chimpanzee adenovirus modified to carry and deliver coronavirus genes into human cells) in the U.K. and India, as well as Phase 3 trials in Brazil, South Africa and the U.S.23 According to STAT News:24
“The [AstraZeneca] spokesperson described the pause as ‘a routine action which has to happen whenever there is a potentially unexplained illness in one of the trials, while it is investigated, ensuring we maintain the integrity of the trials.’ The spokesperson also said that the company is ‘working to expedite the review of the single event to minimize any potential impact on the trial timeline.’”

AstraZeneca Vaccine Has High Rates of Side Effects Too

Like the Moderna vaccine, the AstraZeneca/Oxford University vaccine also appears to come with a shockingly high rate of side effects. Results25 from one of its Phase 1/2 studies published August 15, 2020, revealed a clear majority of participants experienced side effects. Results showed:26
“Fatigue and headache were the most commonly reported systemic reactions. Fatigue was reported in the ChAdOx1 nCoV-19 group by 340 (70%) participants without paracetamol and 40 (71%) with paracetamol …
Headaches were reported in the ChAdOx1 nCoV-19 group by 331 (68%) participants without paracetamol and 34 (61%) with paracetamol … Other systemic adverse reactions were common in the ChAdOx1 nCoV-19 group:
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Sportsbet.io Casino Review

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BODOG Casino C$600 bonus and 50 no deposit free spins

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BODOG Casino Review
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BODOG - the online casino in Canada!
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Bodog Casino Review

Among known brands in online betting and casino gaming, Bodog is without doubt one of the best. Since 1994, when Calvin Ayre launched it, the site has gone through many development phases. There was a time when it was one of the foremost online gambling options for folks in the United States; however the site no longer accepts American customers. Its sister site, Bovada, is now left with that task.
Presently, Bodog is entirely focused on the Canadian market and accepts customers solely from this region. Some of the gaming options available at the site include sports betting, casinos, horse racing, and poker. While sports betting has been the primary focus of the site, other features are also very inviting, with casino play now being more prominent than ever.
Below is a comprehensive review of the site, looking specifically what Bodog Casino offers players and whether or not this casino website is worthy of acclaim.

Going Through the Motions

You definitely are going to be impressed when you check out the Bodog Casino website. The home page is very simple, however it makes it very clear what the site is about with bold graphics, as it does its best to place the spotlight over the games it makes available. You will find links to each of the main sections of the site, and a noticeable link to register an account.
If you click the link to open an account, a new window will display and you will have to enter your country of residence, along with other relevant registration information. At present, only Canadian residents may use Bodog Casino.
The sign up process doesn’t take long; basically you just have to provide a few small pieces of personal information. This includes your name, email address, and date of birth among other things. As soon as you’ve concluded the process, your account will be registered and you’ll be able to start betting and gaming as you see fit.
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Just One More Spin

Bodog Casino puts its budget to fantastic use, as it provides players with advanced graphics and an incredibly smooth gameplay experience across all casino game games. Focusing in on what is most impressive, table games like craps and roulette, along with card games like blackjack and poker are particularly enjoyable.
Bodog Casino blackjack has also long retained the reputation of being one of the most effective casino games on the Internet, as it never fails to disappoint. Bodog Casino slots are increasingly improving with each new release too, which shows that this is an online casino that is making progress. When it comes to games, Bodog Casino is sleek to say the very least, as through one click of the mouse a game is started instantly (no registration is needed to play for free).

Quit While You’re Ahead

Depositing and withdrawing at Bodog are both straightforward. Visa or Mastercard can both be used to deposit, and the site is excellent at getting credit card deposits processed fast too. A few other methods are available as well, like BillPay and Interac e-Transfer. There’s no charge for depositing, and funds will normally be ready for you to make use of instantly.
Withdrawals are usually processed within a fairly good timescale; you can expect to have your funds within a couple of days in most cases. You can withdraw via cheque or direct bank transfer, as well as Visa. Although it must be noted that only specific Visa cards are eligible though. All customers are entitled to a minimum of one free withdrawal per month, but charges are applicable on all successive withdrawals.
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The Perfect Leg-Up

There are three welcome bonuses offered by Bodog, one for each of the main products it has to offer. The sports betting bonus is designed to match 100% of your first deposit, up to $200, with just 3x rollover requirements in place. There’s $600 available for new players at Bodog Casino, which is split into two different bonuses formats for slots and other games. While for those who have a specific interest in poker, Bodog Casino puts a tempting $1,000 bonus up for grabs.
Bodog runs several other promotions too, so there’s plenty of extra value to be found here by regular customers.

Classic Canadian Custom

Awful customer support can surely bring down a gambling site, but thankfully Bodog Casino doesn’t suffer from this. The customer support there is great, and that truly enhances the overall feel of the site. Should you ever stumble upon a problem, or just have an inquiry you want answered, you can be assured of a speedy and useful response. You can get in touch with a member of Bodog Casino staff via e-mail or phone, and there’s an alternative to submit any queries directly from the on-site contact page too.
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Bodog Casino is an excellent place to play casino games; it really is just that obvious. Their online casino is of the highest standard, with a terrific collection of games put on show. The majority of these games can be played through their download software option or the instant play alternative, and they’re also many mobile games available too.
The variety of slots is extremely impressive, with some appealing jackpots on offer. At this point in time there are not any live dealer games at hand, which is probably the biggest disappointment here. There’s unquestionably a lot of fun to be had at Bodog Casino, and there’s a rewarding customer loyalty scheme in place for regular players as well that only heightens the playing experience.

Put on Your Poker Face

It’s without doubt fair to state that poker isn’t the central priority at Bodog Casino. Even though its poker room isn’t quite up there with the very best, it’s still of a decent standard. The focus of such is placed on casual players, given by their use of anonymous tables to circumvent the use of monitoring software that many serious players make use of.
As a consequence there’s very little of high stakes action, and there’s also not much in the way of advanced features either. However, these criticisms are considerably minor, and there’s one huge advantage to playing here. The focus on casual players means the all-round standard of the opponents you’ll find isn’t that great. This provides lots opportunities for making some cash if you are a relatively good player.
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Every Dog has its Day

Bodog Casino is generally well liked by the online casino masses and it is fairly easy to see why. They are trusted and they have been around for quite a long time now, with this experience now beginning to shine through in the casino platform they make available. Dare we say, the only real issue we have is that they only accept customers from Canada. Of course, this is great for Canadians, but not so great for people in other parts of the world, as they’re missing out on a truly entertaining online casino experience.
Conclusively, all gambling websites have their shortcomings, and Bodog Casino isn’t exempt from criticism. But the criticism we have however is all relatively minor, and the strengths surpass the shortcomings at Bodog Casino by a country mile. It may have gone under the radar in the past, but it looks like Bodog Casino is now stepping out, with more and more players becoming aware of what this casino has to offer.
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Bodog Canada Casino 100 free spins + 100% up to $600 bonus

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Game Software and selection

The online casino side of Bodog is supported by two separate software providers. While Real Time Gaming might not have the newest or shiniest games out there, it provides sufficient variation when it comes to all your favorite classics. Thanks to the use of RTG you get a wide choice of blackjack, baccarat, roulette, and video poker to keep you entertained. There are no live dealer games available at Bodog casino yet but there is a wide choice of everything else!
However, the real stars at Bodog are the Betsoft games. They are perfectly rendered movie-like creations, but besides feasting your eyes on them, you can also win money from them. It is a pretty sweet deal! In addition, Bodog offers a bunch of player guides to lead you through the process of picking a game, learning how to play it, and even following the etiquette of online casinos! And if that is not enough, every game has its own 'How to play' section and a detailed description, so you can go in prepared! Some of the slots that you have to try out are Cleopatra's Gold, Caesar's Empire and Madder Scientist, to name but a few.
It is important to note that Bodog does not cater to professional players, as can be seen in the amount of support and information they provide to their players, and the fact that the highest bets that one can make at one go do not go over C$500. This is a casino that caters specifically to recreational players, even giving them the facility to remain anonymous at the poker tables.
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Bodog Poker Review

Online poker betting is a big feature of online gaming and Bodog offers a medium-sized poker room for fans of the game. While you can only play up to 15 tables simultaneously, that fits in with the ethos of the casino and its dedication to recreational players. When it comes to poker, Bodog also offers anonymous tables where no one know the others' online handle and everyone is given a number. In this way, the odds are evened out. This might not seem appealing to pro players but recreational players will find it a refreshing breath of air compared to other poker rooms. There is also a number of poker tournaments organized by Bodog poker room over the span of each year, which are a good place for more experienced players.
The thing about playing poker on Bodog is that if you do it from your computer, you have to download the Bodog app. That does have its advantages, as having the Bodog app allows you to also access the whole range of Bodog casino games, so once downloaded, you can play both poker, and everything else, straight from your computer. Signing up for Bodog's poker room can also make you eligible for a bonus of up to C$1,000, so it is a good place to start if you are a new player just getting into poker.

Bodog Sports review

Bodog sports betting is one of the best sites to go to if you are into betting on sports and you live in Canada. Football, basketball, hockey are all to be expected in a sportsbook but Bodog also offers political bets, and even wagers on topics connected to Entertainment. For example, you can bet on who will win Big Brother Brazil or who will be the next Game of Thrones character to die in the series! This makes Bodog the right side for betting if you are looking for something less ordinary.

Bodog Mobile review

To play on Bodog from your mobile device, all you have to do is open up your browser and sign up for a Bodog online casino account. Since the latest overhaul of the website there is no software to download for mobile use, which is great news for Apple devices! This also makes the casino lighter and easier to use than many of its competitors. Basically, any mobile device capable of running html5 can be used to place bets on Bodog. So if you have an iPhone or an Android you will be able to access your Bodog account and play online poker or place bets on horse racing. If you prefer your iPad or your Toshiba tablet, you will do just fine with the Bodog mobile site.
What if you don't own the latest iPhone or a Samsung Galaxy, or a Huawei P9? What if you are a Blackberry fan? Fear not, Bodog caters for you, too, with a mobile-optimized page that will open just right on your device screen! So even from your Blackberry, you can still partake in Bodog's mobile poker.
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Banking options:

Bodog does not offer a wide range of accepted banking methods, but it accepts some of the most popular ones, which makes up for the lack of variety. You can always use your Visa or Mastercard for deposits, even if they are anonymous prepaid cards. Another major payment method for Bodog online casino is the instant e-check and still another the Interac e-transfer, which allows you to use your online banking services to deposit.
The top withdrawal method for Bodog is actually via check. Bodog issues up to one fee-free check a month for up to C$3,000. Recently, the casino also introduced Bitcoin and now they even offer a tutorial describing how to create an account and use Bitcoin for betting. This can be a good method if you prefer to remain anonymous.

Security and fair play

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Bodog review in 2020: Conclusion

The Bodog website is a big place which offers a number of different types of gambling. It uses two types of game software, which makes its games more interesting and diverse, and it has strong customer support all around the clock. It accepts a sufficient number of payment methods, including Bitcoin, which is gaining popularity rapidly and offers some strong welcome bonuses to start you off.
It is only open to Canadian players, works in Canadian dollars, and it does not accept professional players but that means that if you are a Canadian beginner or a recreational player, this casino is made especially for you. And whether you are into horse betting, sports betting, casino or poker, Bodog will offer you the best service and betting options on the market.
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How to Take Advantage of the Mobilewins Free Bet

How to Take Advantage of the Mobilewins Free Bet
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Why Claim Boylesports Free Bet

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2020 Psychedelic Industry Insights Report

By: Nikita Alexandrov BChem, MBA - CTO, ThinkMyco
Jan 8th, 2020
2019 was a pivotal year in the psychedelic industry with US decriminalization actions, two companies receiving FDA breakthrough status for psilocybin, funding of the $16M Johns Hopkins Psychedelic Research Center, The US Defence Department starting their rumored $20M+ Focused Pharma psychedelic science program and the movement of top universities into research and clinical trials. With the explosion of the more than $100M dollars worth of investable psychedelic opportunities in Q3 2019, the collapse of high quality cannabis investments, one of the best Decembers on record and a potential $1B scale psychedelic IPO - 2020 will be the year of psychedelic investment.
The movement in the field recently is just a blip compared to what is to come, this industry has been brewing for the last few decades. Big Pharma has failed when it comes to new approaches to brain and central nervous system treatment. Due to poor understanding of mechanisms, complex clinical trials and systematic side effects, Neuro drugs have half the success rate of all Pharma projects, which caused most of the big players to reduce or cut their Neuro programs in the last decades. Recently, engagement is exploding with new clinical legislature supporting Neuro and the recent approval of 3 potentially blockbuster Neuro drugs in the last 2 years,
Q2 2019 saw a record of over $320M in investment into Neuro drug development. Interestingly enough an influential group of ultra-high net worth individuals including PayPal founder Peter Thiel funded the psychedelic holding company Atai Lifesciences which went on to fund Compass Pathways and continues to fund commercial efforts in this field. Atai Lifesciences recent movements are a familiar story of acquisition and consolidation in an emerging market which will be a common theme in the future of the psychedelic industry. In 2019 Atai Lifesciences acquired Perception Neuroscience and GABA Therapeutics for their next generation tranquillisers. Last week, Atai also acquired NeuroNasal, a non-psychedelic company creating a concussion nasal spray. In partnership with pharma, Atai's recent launch of EntheogeniX, an AI based psychedelic drug discovery platform, shows that Atai is serious about making investments into the fundamental research required to continue being an industry leader in the long-term. It is rumoured that Atai has made a number of cash investments recently, so new partnerships and acquisitions should be expected in the next months.
The collapse of investable cannabis opportunities are driving investors comfortable in stigmatised industries and binary risk to the table with big pharma, cutting edge science and huge unmet market needs to create a perfect storm of opportunity.
Highlight:
Investors seek 'mega blockbuster' drugs as neuroscience undergoes renaissance
How big is the Psychedelics Industry?
Historically, the psychedelics industry has been fragmented with around $60M worth of companies in the last 20 years, many of which were not sustainable. The current industry is around $220M+ worth of investments, dominated by the Peter Thiel backed Atia Lifesciences at $100M+ and Compass Pathways at $50M+, followed by Mind Medicine at $10M+, Fieldtrip Ventures at $10M+ and then a 10-25 early companies in the range of $2.5-10M each. The $220M+ worth of investable deals have only existed since the public formation of Compass Pathways in 2016, with the majority leaving stealth mode in 2019.
Highlight:
Transforming psychedelics into mainstream medicines
How big is the Psychedelics Market?
The psychedelics market is emerging while highly coupled to clinical/regulatory events and is split between recreational and medical psychedelic markets:
Recreational: $8-19.2B
Calculated from cannabis market and comparable usage prevalence as well as demand size economics.
Medical: $373B+
Calculated from the main markets addressable by psychedelic therapeutics (neurogenics market): mental health drugs, therapy spending, neurodegeneration drugs and cognitive enhancement.
Highlight:
Analysis of the Psilocybin Pharmaceutical Market
Who are the players?
Atai Lifesciences - German based, Global psychedelic pharma holding company formed by ultra-high net worth individuals and big pharma, $100M+
Compass Pathways - London based psychedelic giant, Atai's bet on psilocybin as an approved drug for depression, $50M+, IPO 2020
Usona Institute - A Wisconsin based non-profit powerhouse competing with Compass Pathways to approve psilocybin for depression.
Mind Medicine - Toronto based ibogaine derived addiction drug development company taking their lead candidate 18-MC through the clinical approval process, $15M+, RTO in 2020
Eleusis Benefit Corporation - New Orleans based discovery/clinical stage Psychedelic pharma company supported by industry scientists, raising $25M
FieldTrip Ventures - Toronto based, Aurora backed magic mushroom research and development company building clinical and production infrastructure, raising $12M+
ThinkMyco - Vancouver based holding company developing disruptive mushroom production technology and next generation therapeutics, raising $5M+
Gilgamesh Pharmaceuticals - Psychedelic drug discovery company affiliated with the Atai owned Perception Neuroscience and Columbia University, raising 10M+
Universal Ibogaine - Vancouver based Ibogaine clinical development company franchising the world's most advanced ibogaine clinical model, raising $10M+, RTO in 2020
PsyGen Labs - Alberta based psychedelic mass production and clinical research company with highly experienced production chemists $8M+
Entheogen Biosciences - Vancouver based company pursuing psilocybin and DMT based drug development, raising $3M, IPO in 2020
Salvation Botanicals - A Vancouver based company touting a private controlled substances site license and supporting clinical research, raising $10M+, RTO in 2020
Numinus Wellness - Vancouver based wellness company building testing as well as clinical infrastructure, partnered with Salvation, raising $5M+, RTO in 2020
Cybin Corp - Toronto based research and development company building drug development and production infrastructure as well as nutraceutical assets in legal jurisdictions, raising $3M
Emerging Players - There are a number of emerging players, around $35M+ in emerging deals in Q3 2019 which have not passed due diligence.
Clinical:
Recent data is showing psychedelics can be real mega blockbuster Neuro drugs. Johns Hopkins recent trial on Psilocybin for smoking cessation showed an 80% success rate in terminating nicotine addiction, more than double any known therapeutic approach, including nicotine replacement therapy. This is showing addiction can be treated with new mechanisms that are much more low level than replacing the drug in the receptor. Academic data unequivocally shows that Ibogaine is 95% successful in terminating acute opioid withdrawal symptoms permanently from a single dosage. Limited data from long-term Ibogaine for opioid addiction trials show 50% success rates in terminating addiction in the 6 month period with a single dosage, more than 10X higher than the generous 5% success rate of other approaches in the 6 month period. Data from leading Ibogaine providers like Universal Ibogaine show that this 50% figure can be pushed closer to 75% with proper protocols and aftercare. Clinical trials on Psilocybin for cocaine/crack addiction are ongoing at the University of Alabama at Birmingham, a top 20 medical research university. 10 patients were un-blinded for bioethics review and the unpublished data shows that 30% never touched crack again while the other 70% had a relapse or two and turned their lives around, showing a 100% success rate in changing lives with minimal cost. When this data is available publicly in the next years, tidal waves of interest will move into the field.
Highlight:
Psychedelic Clinical Research Timeline
Projections:
As a recreational market, 0.1% of the population was surveyed as using psychedelics in the last month, placing the current black market at $19.1B while as a comparable percentage of the legal cannabis market adjusted for prevalence would place it at $8B.
As a medical market, the $373B neurogenics market seems to be the addressable market. Penetration into any indication in the neurogenics market would reap vast rewards. Psilocybin is on track to compete in the depression market with two FDA breakthrough designations, a 2% penetration into the depression market would being $1.4B+ in value yearly. Ibogaine's very reasonable projected 5% penetration into the opioid dependence market in the next 10 years will bring $9.6B+ in value yearly to groups like Universal Ibogaine which are deploying clinical infrastructure, supporting clinical trials and controlling the Ibogaine supply chain. Of all of the indications in current psychedelic clinical trials, not considering crossover, they address a $400B+ market, with projected penetrations across each indication and adjustments for market factors, it is projected $16B+ of value yearly will be created from commercialisation of the current late stage clinical trials which are in progress.
Highlight:
Johns Hopkins Psilocybin for Smoking Cessation Data
Challenges:
Regulatory Challenges:
While nearly 100 cities are creating legislation to decriminalize psychedelics and multiple US jurisdictions have passed decriminalization, federal changes will be required to open legal markets to the full potential. While investing in the binary risk of regulatory changes is standard in the junior markets, current regulatory controls are preventing early revenues. Many Canadian companies building production and distribution infrastructure offshore in jurisdictions such as Jamaica are operating in a legal grey area. While it is legal in Jamaica, any benefit or advantage given to a Canadian company could be considered a proceed of crime including IP development, capital repatriation and validation of technology offshore. Section 56 exemptions from Health Canada are required for Canadian companies working with psychedelics offshore and companies which are raising investment dollars without a secured Section 56 exemption may be incurring legal risk.
Cardiac Liability:
The unspoken elephant in the room of psychedelic derived pharmaceutical acceptance is not regulation, for example Ketamine is a scheduled drug which was recently approved for the general market. The problem is actually the liability of bringing a seratonergic based drug to the market like Psilocybin, DMT and LSD. The crippling withdrawal of blockbuster drug Fen-Phen and issues with other drugs like Imitrex due to seratonin agonist effects on the heart have scared the FDA into a position that any seratonergic drug will require extreme cooperation and diligence and will absolutely incur additional clinical and monitoring costs over other drugs. Psilocybin while technically hitting the 5ht2b receptor which causes cardiac side effects, does not have a high enough affinity to be a deal-breaker, meanwhile LSD having a very high affinity will cause large barriers for groups attempting to bring microdosed LSD to the market. Ibogaine suffers from cardiac liability due to an entirely different mechanism and unlike Psilocybin or LSD, adverse events have been reported. While Methadone and other standards of care also have the same long-QT cardiac liability at much higher rates and significantly higher mortality rates , Ibogaine clinical models must pre-screen patients for existing heart defects before procedures to guarantee no adverse side effects.
Banking/Insurance/Exchange Issues:
Legitimate psychedelic derived drug development companies have already had bank accounts halted at multiple banks for involvement in this industry and moving forward similar challenges faced by the cannabis industry should be expected. Exchanges and public offerings will have logistic challenges with this industry and minor friction has already been seen in the listing process. DNO insurance and other underwriting will be required to list in large markets and to date no psychedelic company has been underwritten, although underwriters and leading insurance brokers are actively exploring his industry.
Reimbursement:
The real whale will be insurance and single payer reimbursement of psychedelic derived pharmaceuticals on the market, allowing for global market uptake. Health systems have traditionally been decades behind the state of the art as seen in the point of care and home diagnostic device market, a market which could keep people healthy at minimal cost but has been crippled by lack of reimbursement.
Supply Chain Commoditization:
The production and control of psychedelic supply chains which is the familiar play of the cannabis industry will be a race to the bottom with magic mushrooms and other psychedelics. Production models are competing with a much more fluid black market and are being cannibalized by low cost home production and wildcrafting of psilocybin mushrooms. The LSD or ergoloid supply chain is highly monopolized, with the majority of the worlds ergoloids being produced in a single location. Companies competing in the production and supply chain space will face heavy price pressure and a highly coupled global regulatory system. The single outlier is Ibogaine, with a current global use estimated around 90kg, expected to reach 280kg in the next few years, this is a commodity whose price will drive through the roof. Large ibogaine producers have stopped production and natural sources are not commercially viable, with an Iboga plant producing maybe a single dose on the 10 year period, the move of Ibogaine to endangered status in 2019 and no synthetic GMP producers - the Ibogaine market is legal in the majority of the world and exploding while highly underserved and fragmented.
Delivery System Challenges:
A number of recent psychedelic deals are built around new drug delivery systems for psychedelics entering the recreational market to build expertise and infrastructure ready to move into the pharmaceutical market. Many of these technological approaches will not translate from the recreational market to the pharmaceutical market such as CBD/psychedelic compositions, natural product compositions as well as vaporizer and inhaler based delivery systems. While 20%+ of all new FDA drug entities are derived from natural products, natural product mixtures containing many products and a controlled substance have never and will never be FDA approved due to the regulatory system. Companies developing Psilocybin/CBD combinations and related therapeutics for the recreational market should understand that unlike the cannabis market, recreational approaches will not translate directly to medical approaches.
Opportunities:
Syndicated Investments:
One of the largest opportunities in any emerging market is syndicated investment, a 2002 analysis of 584 venture backed exits showed that syndicated investments produced double the rate of return of non-syndicated investments. Psychedelic research and development companies require standardized infrastructure that can be leveraged across a number of players. The big players entering the industry are more interested in empire building, requiring massive consolidations of commercial efforts which can be facilitated by syndicated investment groups. Companies like ThinkMyco, Entheogen Biosciences and Cybin Corporation which focus on technology development, IP Portfolios and early stage drug discovery will benefit the most from syndicated investment and collaboration. A Harvard Business School review of Pharma discovery programs statistically compared drug discovery programs to weapons research programs and found in these high reward/low incremental cost programs the optimal path is to run parallel programs, with an average Pharma drug discovery program having 16 parallel programs, 10 core and 6 low budget/high risk. At the current moment, around 5-10 psychedelic investment funds are forming in the range of $10-50M each, including the Cannacord Genuity backed Entheos and the $20M psychedelic quant fund Tabula Rasa Ventures.
IP Portfolio Development:
IP development is the highest value for dollar on the investment value chain and the psychedelic industry will be a totally IP driven industry. The most valuable patent portfolios will include new psychedelic compositions and therapeutic mechanisms, which require significant investments into fundamental R+D, while less competitive portfolios will include delivery system/psychedelic combinations.A recent review of patents related to psychedelics shows many hundreds of patents for psychedelic derived therapeutics with only a small cross-section being commercially competitive. DemeRX, the $40M+ Ibogaine research company holds 65+ patents in the ibogaine therapeutic area. While DemeRX filed for bankruptcy and their research and development assets were liquidated, it is rumored they have been injected with enough capital to come back to the party - this is a dark horse to keep an eye out for.
Mushroom/Protein Connection:
The real opportunity in magic mushroom production models is flying under the radar: protein production. Mushrooms are one of the highest quality sources of nutrition and protein, if you took a vitamin C supplement you can live exclusively off mushrooms. Dried mushrooms have basically the same protein percentage as beef and in terms of grams of protein per acre per year are 100 fold higher producers and much more sustainable than traditional agricultural practices. Companies in this space which invest into real R+D for lower cost mushroom production will get a lift from the $1.8+ trillion dollar protein market. A recent review of mid-sized mushroom farms shows that 50%+ of the cost of mushroom production is due to labor and technical inefficiencies. If energy, labor and materials cost drivers can be reduced, and the cost of growing a pound of mushrooms can drop from around $2 to around $0.75 through automation, mushroom protein becomes significantly more commercially competitive than many of the industry leaders in plant based protein like pea protein. If energy cost reductions can drop the cost even further, mushrooms will become a disruptive food source. Psychedelic companies building mushroom production infrastructure will be well served to remember that by investing in automation, new technology and new growing systems the price of mushroom based protein production can make it more competitive than any other food source. The largest food security report in history was released Q2 2019 and showed that without subsidies a hamburger would cost more than 30$ and the meat industry will economically collapse by 2040, the protein game is looking more and more attractive as a hedge against the regulatory risk of magic mushroom production.
China:
China is one of the most advanced markets in terms of size and pharma spending, as well as venture investment. Traditionally the Asian cultures had no interest in marginalized and politically tense areas such as drug medicalization but the movement into CBD and China's rabid interest in plant medicines may create a large influx of Asian capital moving into psychedelics. This industry shifting action will be leveraged by education and the court of public opinion. A dialog must be created showing psilocybin as a plant medicine and not a drug of abuse. Interestingly enough, Chinese firms have very recently started producing magic mushrooms industrially and importing them into the Canadian market where they are sold into the black market over-the-counter in some Canadian herbalist stores.
Ibogaine:
Ibogaine is the only psychedelic model which will not be very quickly commoditized. Ibogaine as a solution to the opioid problem is a disruptive technology, with the rise of fentanyl and fentanyl analogs like carfentanil dominating global supply chains, Buprenorphine, the preferred standard of care is no longer effective and produces a life threatening condition called Precipitated Withdrawal. This is due to the aggressive affinity of fentanyl to receptors, the lack of tolerance ceiling and the little understood metabolism of next-generation fentanyl analogues, dramatically compounding a problem already at pandemic levels. Ibogaine supply chains have collapsed at the same time that demand is growing exponentially, the firm which dominates the current global ibogaine supply chain will reap around $1.4M/mo profit serving the current global demand. One of the largest African Ibogaine brokers has seen a 30x increase in sales from 2017 to 2019. With Universal Ibogaine taking Ibogaine through the Canadian clinical process and the grassroots support from Health Canada, Ibogaine will be the first psychedelic approach available to consumers. While Ibogaine is a scheduled drug in the US and some European jurisdictions, it is not scheduled in Canada and the majority of the global market. Multiple Ibogaine documentaries are in filming, including actors such as Johnny Depp, as this is an education driven industry, we should expect exponential growth to accelerate in 2020.
Support Industries:
Industries supporting the growth of psychedelics will be a large part of the future landscape as was seen in the cannabis sector. A psychedelic business support network including education, conferences, business analysis and financing have already cropped up commercially. In Q3 2019 the renowned Cambridge House International Extraordinary Future conference created a panel for psychedelic opportunities. Two weeks before the conference there was a frantic rush and the majority of relevant psychedelic players were represented last minute in the panel discussion including: Compass Pathways, FieldTrip Ventures, Mind Medicine, Johns Hopkins, Dennis McKenna and ThinkMyco. Multiple psychedelic investment funds are forming alongside of industry press, consulting groups and other support interests. In Q3 2019, Dr. Matthew Thompson of Johns Hopkins and Dr. Charles Nichols of LSU/Eleusis Benefit Corporation helped organize the inaugural conference for the new journal called International Society for Research on Psychedelics in its home of New Orleans. Over 100 international scientists from top universities were represented, with the conference having to turn down many late registrations. Dr. Rolland Griffiths, head of the Johns Hopkins Psychedelic Research Center said "This was the best scientific conference I have been to in my entire career.".
Sub-perceptual dosing:
Microdosing was popularized by Silicon Valley, catalyzing the resurgence of the psychedelic industry but microdosing is a protocol built on unsound fundamentals. Research shows that the therapeutic effects of psychedelics are highly dose dependant, higher doses lead to better therapeutic effects. The microdosing supply chain model has excellent returns, with a pound of mushrooms costing less than 5$/lb to produce which provides around 1200X microdoses. When dosages increase past the perceptual threshold, the potential for adverse events such as bad trips exponentially increases. The ideal dosage seems to be just under perceptual threshold where you can still go about your day, but much higher than a microdose. This is industry standard with seratonergic pharmaceuticals, an example being the diet drug Belvique, which is closely related to psilocybin, dosed at the perceptual threshold for maximum effectiveness. Belvique can cause psilocybin like hallucinations if 4 tablets are taken as it is a seratonergic drug. High doses of psilocybin require a clinical infrastructure and in-patient experience, dramatically increasing costs and logistics overheads. Sub-perceptual dosed pharmaceuticals will be available for out-patient and take home treatment and in many cases may be as effective as full blown psychedelic experiences. Mind Medicine, ThinkMyco and Eleusis Benefit Corporation are leading the charge in sub-perceptual therapeutics.
Next Generation Drug Development:
Mind Medicine is taking the approach of engineering the hallucinations out of the therapeutic experience by removing parts of the molecule and are moving their drug, 18-MC through the clinical process. This is the ultimate high risk/high reward play in the psychedelic industry. 18-MC is modified which also changes a variety of important receptor binding effects. The modified receptors include the receptors responsible for neural growth factor release, cognitive effects, cardiac effects and the opioid system coupled NMDA receptor system. Since there is no data on the human use of 18-MC in opioid addicts, significant capital must be deployed before it is even known if 18-MC is as efficient as the parent molecule Ibogaine for treating opioid addiction, the ability to treat addiction in an out-patient setting with no cardiac toxicity - 18-MC will be the megablockbuster all investors in the neurogenic space are waiting for. ThinkMyco, Gilgamesh Pharmaceuticals, Mind Medicine and Eleusis Benefit Corporation are leading the field in next generation drug development.
Lateral Drug Development:
While psychedelics address a $373B neurogenics market, companies such as Eleusis Benefit Corporation are showing they can address other unmet clinical needs such as chronic inflammatory disease. Eleusis is developing new psychedelic compounds for the treatment of inflammation, specifically within ophthalmology, and has recently published Phase I trial results revealing the safety and tolerability of low dose LSD in healthy older adults, with the intention of evaluating low dose LSD as a disease modifying therapy in Alzheimer's disease. Eleusis Benefit Corporation looks poised to cannibalize the $3B steroid therapeutic market. Not yet published research is showing Ibogaines potential as a therapeutic to treat sleep disorders. Johns Hopkins is currently reviewing the application of psychedelics in pulling patients from comas and vegetative states. The original pre-Mind Medicine clinical trials on the Ibogaine derivative 18-MC showed promise in treating Leishmania infection. BOL148, an inactive form of LSD, originally the placebo in human clinical LSD research, was found to in some cases to permanently terminate cluster headaches after a few doses and is being publicly demanded from the cluster headache community. These are the earliest days of understanding the application of psychedelic derived chemistry as new therapeutic approaches.
Public Health Engagement:
Looking at recently released data representing North American, working class adults, methamphetamine and fentanyl use is growing enormously and consistently. Linear regression of growth rates over the last 5 years projects a 380%+ increase in Fentanyl usage the next 15 years, with Methamphetamine projected at a 475%+ increase. This is concerning as there are more than a million high quality data points over 5 years and an R2 value of 90%+ which paints of picture of statistical certainty. This shows that the opioid crisis has moved from a lift caused by supply side drivers to an organically growing demand side driven pandemic, fueled secondarily by histories cheapest and most available synthetic drugs. With Johnson and Johnson settling with two counties in Ohio, projections have placed the total at $100B+ in fines for the opioid crisis in the next few years. State jurisdictions will shortly receive an enormous amount of cash that will be legally obligated to flow into anti-addiction spending. Due to poor outcomes and non-scalable approaches around advanced public health programs, there will be a flurry of legislature to address how to spend the $100B+ anti-addiction warchest. Players like Universal Ibogaine who have proven clinical models, can deploy infrastructure and guarantee statistically better outcomes will receive unprecedented amounts of non-dilutive government funding and will be the first to benefit from Decriminalization/Medicalization in the North American market. Players that can come to the table now at the state level and propose medicalization legislature as well as profitable clinical infrastructure with proven outcomes, could monopolize the entire US market. FieldTrip Ventures is developing Psilocybin clinical infrastructure while Universal Ibogaine is deploying proven clinical infrastructure already developed and proven by Clear Sky Recovery, the leading Ibogaine clinical experts with thousands of successful detox procedures and no critical adverse events.
Closing:
Like any emerging industry, there are challenges and growing pains but the blue-sky upside is unparalleled. "Black swan events are characterised by their extreme rarity, their severe impact, and the practice of explaining widespread failure to predict them as simple folly in hindsight." Due to changes in public opinion, a mental health and addiction pandemic as well as enormous movements of liquid cash, this sector is poised to explode in 2020.
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submitted by freispiele to u/freispiele [link] [comments]

Review Fallout Wastelanders by Gamekult (one of the most important video games magazine in Europe)

For all those who stubbornly wait for Wastelanders, here is a test of the specialized site Gamekult (one of the most important JV sites in Europe) which through many details explains to you why it's a scam!
Fallout 76 : Wastelanders review by Gautoz
What is Wastelanders? A massive, free update that reintroduces the human presence it lacked when it was released to the Wastelands of Fallout 76. A history rewrite, automatically downloaded to your machine if you own the game. "But no, Bethesda never released Fallout without NPCs! Where the only humans would be players connected to 16 per server? With audiologs as the only speakers? Haha, but that would be completely idiotic!". So, a year and a half after the crash, it's not a matter of patching up a small portion of the game, but of covering the entire philosophy behind the Fallout 76 experience with a tarp. Philosophy that you can read about at length in our vintage text, available in the tab just above this paragraph.
(Paragraph translated in another post)
So we are forcibly bringing human NPCs back into this imagined world to exist without them. Some dungeons are converted into peaceful landmarks to welcome the (two) factions imagined for the occasion. We assemble from scratch a system of dialogue, completely absent from the game released in late 2018, to let players choose how to approach each exchange and even highlight certain abilities (Intelligence, Strength, Charisma). A new main quest is designed from scratch, with missions that often send you to visit slightly redesigned versions of existing locations, new encounters and a few new places. An arc of quests is written for each faction, and the inevitable moment when the game will ask you to choose a side just before the grand finale. And that's where Bethesda's incredible feat lies: resurrecting many of the elements traditionally associated with the RPG genre and the series' story without injecting an ounce of role-playing into Fallout 76. Not a single one.
Before elaborating, let's take a first parenthesis. What doesn't Wastelanders do? RPGs, we just said that, but what else? It also doesn't provide the technical rescue so much demanded by a good part of the game's buyers. Even with this big content package, Fallout 76 is still the game with a hole in it that no big publisher with any regard for its image would dare to present as a finished product. With AI crashing over and over again, frequent visual glitches, flickering textures, out-of-date animations, back to the desktop, server instabilities, scripts that don't start or start sideways, quest bugs, a sound engine unable to provide basic position and distance information, and an incredibly dusty interface, it's all still there, unchanged, as it was for Skyrim, Fallout 3, Oblivion, and somewhere in between for Morrowind. Not a minute goes by without a technical accident, big or small, breaking the immersion and reminding us that the Bethesda Creation Engine deserves only one thing: that we drag it by the hair to the bottom of the garden and shoot it with two rounds of buckshot in the back of the neck, in the name of this game and those that preceded it.
The motor, however, is only a tool. And at the end of the stick is a studio which, game after game, has been sweeping its increasingly shameful technical balance sheets with the back of its hand or even making jokes about them. Bethesda's delirious cynicism has reached a new level with this Wastelanders, a content pack that under the guise of Fallout 76's Steam arrival on the scene is being told as a kind of "relaunch". Somewhere, and of course without saying so, in the vein of Final Fantasy XIV A Realm Reborn and No Man's Sky. What he fails to mention, however, is that players were looking for a functional AI, good shooting feel, and overall a game that didn't have the feel of an amateur mod for Fallout 4. That the company that promised to find solutions for fans who wanted to play offline (or at least in controlled groups) ended up packaging their requests as private servers, available for 15 euros per month through the Fallout 1st program.
That concerns about inventory clutter and the hero's hideout are still valid, but the game's crafting menus have been updated to include invitations to visit the in-game store. That even a basic section like the world map is randomly hidden by ads for the same shop, which offers not only cosmetic items but also craft boosters and storage space extensions. What is Fallout 76 Wastelanders? A Trojan Horse that wants to make up for the redemption of the pure
The notion of make-up is important, because it is central everywhere we look. From a distance, Wastelanders is indeed this massive update, bringing life and meaning back to these once so lonely Appalachians. The dialogue system with skillchecked dialogue options (dialogue options based on the hero's abilities) in its own way suggests that the Fallout 4 era is over, and it's time to put the player back at the center of the experience. Even the faction reputation gauges are there, so you can tell if Operation "I've Changed" is in full swing. The problem is that all you have to do is bend down and scratch the varnish for two seconds to catch a glimpse of the deception. Starting with the dialogues, which boast of offering four, five, sometimes six different options: in fact, 80% of the proposed lines say exactly the same thing in different tones, with more or less humour or absurdity. They only cause cosmetic changes in the responses of the NPCs facing you, and the few choices that weigh in at most allow you to extort a little extra from your mercenary bonus, or to bend a minor detail of history without the slightest importance. The same goes for the famous aptitude tests: these are just bonus dialog options, which lead to the same results as all the others. Proof of Bethesda's lack of investment in her trickery: Wastelanders' perk system remains identical to that of the vanilla game, which means that all the "Charisma" abilities actually offer bonuses for playing with friends, not dialogue-related advantages.
Subsegment - 1
Together is everything (alone)
Don't ask me how that's possible, but even the implementation of multiplayer in the new campaign is not up to par in Wastelanders. Basically, you can lead missions with several people, but that only advances the story of the group leader. The others are just following, don't even have a visual on the dialog and will have to redo the entire mission as group leader to get it validated on their side. And that's what you dream of in a subscription MMO…
Under the guise of "more Fallout 3-like dialogue than Fallout 4-like dialogue," 76's dialectical structure is ultimately identical to that of Episode Four, but with more words displayed on the screen: it's a rail, which sweeps away your refusals to comply with a burst of laughter and twists your opinions to fit the needs of the quest at hand. The craziest part is that Fallout 76 makes no secret of the fact, even laughing at everything from your near-zero grasp of events to the courier quests he entrusts to you. The game's script is based on a single principle: filling. The NPCs often cause a lot of nagging, and a lot of nagging, but they don't say anything. Few characters will be able to find an existence other than "the chick who gives quests to the Brigands", "the mayor of the Survivors". And with good reason: that's about all they embody in the game world. After a first main quest based on tapes to listen to, Bethesda offers you a second main quest, this time based on human tapes. You can answer them, but it doesn't change anything.
The story brought by the Wastelanders update follows the arrival in the Appalachians of the first survivors from other states, structured in two factions (the Settlers and the Pillards) whose interests will have to be tried to marry, at least temporarily. The Settlers are very generally the good guys, with motivations as clear as "living simply and respectfully". As for the Pillars, well, they are not too bad guys, who kill and steal on their own account but with a sense of honor and family. "Not like those freaks you find in the wasteland," as their leader so aptly put it. For there is the good bandit and the bad bandit, the one who takes options for dialogue, and the other, the independent marauder, who draws on sight and deserves only to be used as a training target.
Between the two pacifist factions in West Virginia is the Supervisor, the one whose voice memos Fallout 76 had you collecting in 2018 and who was thought to be dead on a mountainside. Your mentor, who's finally alive and well, has a plan: to take over the gold reserves buried by the United States to rebuild civilization on its pivotal value, the dollar. You stifle an embarrassed laugh, you try as best you can to bend history through dialogue, but nothing helps: that will be your mission. All you can decide is your level of investment in the two quest arcs that aim to prepare for the breakout. That's what the Reputation Gauges are for: they're just cosmetic markers of your progress, which rise when you complete a mission for a faction. You can't knock them down, for example, by coldly executing the faction's leader in front of everyone, since all important NPCs are unassailable. Your bullets just go through, because - GO, ALL IN HAVE THEIR HEART - Fallout-76-is-not-a-role-play.
Subsegment-2
Border Fun
While the Fallout of Bethesda never captured the dark humor characteristic of the first episodes of the series, Fallout 76 Wastelanders is by far the clumsiest in its lineage. Happy to reintroduce NPCs but still not very committed to creating memorable individualities, the studio has turned its attention to creating joke characters. NPCs that exist only through grotesque dubbing or Borderlands-likes gimmicks, who enter the adventure for the duration of a quest and usually leave it once it's over. It was frankly not worth it, especially since the VF (French dubbing version) didn't get the same care as the basic game, with a lot of terms translated out of context and a lot of blunders that do the job.
Whether you choose to ride for the Settlers or for the Pillars, the fare will be the same anyway: all-action linear quests, more or less scripted dungeons to clean up alone or in a group, and dozens of unnecessary round trips for which Bethesda doesn't even bother to make excuses anymore. You'll be sent to pick up an item, and when you get back to the fortress, you'll be told that that other gizmo is missing, as it happens to be stashed in the building next to the one you just got back from. If a character has to be found to take part in the famous central robbery of the scenario, there's a 100% chance that he'll only agree to join the team in exchange for an ubuesque scallion race, or even a series of expeditions structured in ever-growing drawers. While the NPCs joke about what they make you do (what hell), here you are revisiting a corpus of dungeons made up of old, barely redesigned game zones and new instances. Since the bestiary hasn't really evolved outside of human bandits and cultivators, you'll have to eat the ghoul, the mutant and the security robots, always spending five times too much time in the inventory to mitigate the hero's overload, because of all the crap that the game automatically teleports to it at the slightest goal. As we said in the preamble, under the guise of redemption, Fallout 76 hasn't really changed much.
It's important to understand that Wastelanders doesn't completely replace the quest and activity content that Fallout 76 offered when it was released; it's an add-on. That means, among other things, the merry-go-round-style multiplayer activities (events that run in a loop from morning to night and can be sanded down against loot) are always there, constantly invading the interface with giant incentives to come and have fun, adding more and more unwanted stuff to your active quest list. And that goes for multiplayer solicitations, loustics that force their way into your solo exploration, and the three peels in the background that still invite you to switch to PvP. In the same vein - and this is where things get a bit moody - the first campaign that's been so decried by players (audiologs that wander awkwardly across the map like sheep) is not only still in the game, but it's also a must for new players. If the first NPCs who are grabbing level 1 survivors out of shelter 76 suggest that you can choose your campaign (and therefore the lesser evil), it's clear that this won't be the case. A few hours of play later, here's the Supervisor, in the flesh in front of you, who launches you very seriously on the trail of her own audiologs where she "explained everything a year ago". So you have to go grind like a deaf person, because Wastelanders is actually a campaign aimed at heroes of levels 20+, and not the campaign aimed at everyone that the game's communication makes you expect.
Subsegment-3 Grouchy Rando
Ah, October 2018, remember: Fallout 76 chooses to charge for the quick trip in in-game currency, ostensibly to limit abuse between PvP players. Flash forward to 2020: The new Wastelanders main quest makes roundtrips nauseatingly fast, teleports aren't any freer than they used to be, and the game's economy hasn't been adjusted accordingly. Unless you've stacked up thousands of capsules while playing regularly for all that time, you'll have to grind to pay for your fast travels as well. Nice!
The craziest thing in this story of recycling of unanimously decried content? All the grinding in the world won't prepare a new player (or even a dilettante player in the vanilla game) for the zero balancing of Wastelanders quests and dungeons. After underground areas inhabited by level 20 rataupes, the game will send you unexpectedly into the irradiated territories of the West, where the slightest mutant is an elite level 35-40 soldier who dries up all your healing supplies and leaves you drained of blood, good for hours of wandering to loot healing and repair materials all over the place. After that, the story may send you up against ghouls from the very beginning of the game, marauders at level 20, or a level 40 Battle Droid: no one knows. It's as if the campaign points to the next place with its eyes closed and washes its hands of just about everything else. On paper, you might find the idea quite consistent with this notion of an open world focused on survival and resourcefulness. But nothing really seems to be thought through beyond a basic goal: keeping you captive, exploiting the heaviness of the exploration, loot and craft systems to dilute your progress in what was supposed to be - remember - a real Fallout style campaign.
So what's left of Fallout 76? Atmospheric flashes, unforgettable places in the middle of a field of ruins. Rare moments when the immense talent of the people who create the places at Bethesda Game Studios isn't stifled by a technical pantomony or the emergence of a design idea that was already considered grotesque two years ago. This unbearable magnetism that comes with the great universes of the heart that we refuse to let die, that would almost make us change our way of playing to better appreciate the priceless, to get a taste for "atypical" experiences and to better digest cynicism with time. A gigantic Stockholm syndrome that reminds us, one minute of game after another, how the heart is the worst of pigeons and how much Bethesda knows it. The big Wastelanders puppet rejuvenation operation is just the last nail in a coffin that we refuse to see closed. And that, in the end, may be the hardest thing to accept.
Benefits - Always this open world and the stories it tells...
Disadvantages - Finishing, ergonomics, technical assessment: the shame of the giant model even eighteen months later.
Conclusion
It is not enough to flower a cemetery to make a fair. With Wastelanders, Bethesda is attempting a particularly crude double trick. One, watering her game with content rather than repairing the huge holes in her cabin, while betting on her aging monopoly of open world ambience to make the pill work. Two, to make up, disguise, disguise this arrival of NPCs as a real hand outstretched to the lovers of "Fallout, the RPG". And then serve them a linear content, a sturdy, grinding doped content in addition to being without depth or purpose. In special circumstances, new means. Given its revolting technique, even a year and a half after its release, in light of its increasingly questionable business practices, and after witnessing first-hand the cynicism that runs through this Wastelanders relaunch, we decided to lower the original note of Fallout 76. That's a first, congratulations to him.
4 out of 10 (originally 5/10) "weak"
By Gautoz for Gamekult
And for those who will have the courage to read it in French, here is the link of the test : https://www.gamekult.com/jeux/fallout-76-3050878689/test.html
submitted by Sid-harta to Fallout [link] [comments]

Sports Betting with Unibet and Betfair

Sports Betting with Unibet and Betfair
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There are a few terms for this. First players must make a deposit and place a bet of £40 to qualify for this. The games that will be included in the bet must have odds of at least 2/5 or 1.40. If the bet is a winner, the entire amount will be added to the balance of the account. If the bet is lost, Unibet will offer a free bet of the same amount as the stake, but no more than £40. Therefore, the first bet does not imply any risks for the players and it comes with an extra £10 casino bonus.
There are quite a few other aspects to consider when players focus on Unibet as their main source for betting on sports. The perks they offer extend far beyond the sign up bonus offer. Here are a few other benefits you can make the most of with this site: 1. The mobile app – this is a solution to take the betting experience on the go. They offer access to the same features as on the desktop account, including live streaming 2. Weekly bonuses – live betting offers many opportunities and thrills, but on top of that this will also grant access to a weekly bonus of £10. Terms and conditions apply 3. Best odds guarantee – they make sure their players are not exposed to any risks even if odds are lowered after they place their bets 4. Free roll tournaments – placing a sport bet between Tuesday and Thursday will offer a ticket to enroll in poker tournaments with a £500 prize fund. It will introduce players to the world of casino games and it can lead to significant winnings as well 5. Other perks include solutions to boost winnings or to reduce the risks of sport bets

Betfair Bonuses and Perks

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Sport betting sites are looking for active players who are willing to invest in this activity and also engage in it constantly. The more implicated they are, the more rewards they are able to win in the end. One of the best examples in this direction comes from Betfair . This is a site that is going to offer quite a few bonuses as part of the sports betting activity. There are a few terms that must be met to qualify for this, but serious players will be more than satisfied about their solutions.
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I am about to post the 3000 most common words in the English lexicon. Wish me luck...

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temporary ten tend tendency tennis tension tent term terms terrible territory terror terrorism terrorist test testify testimony testing text than thank thanks that the theater their them theme themselves then theory therapy there therefore these they thick thin thing think thinking third thirty this those though thought thousand threat threaten three throat through throughout throw thus ticket tie tight time tiny tip tire tired tissue title to tobacco today toe together tomato tomorrow tone tongue tonight too tool tooth top topic toss total totally touch tough tour tourist tournament toward towards tower town toy trace track trade tradition traditional traffic tragedy trail train training transfer transform transformation transition translate transportation travel treat treatment treaty tree tremendous trend trial tribe trick trip troop trouble truck true truly trust truth try tube tunnel turn TV twelve twenty twice twin two type typical typically ugly ultimate ultimately unable uncle under undergo understand understanding unfortunately uniform union unique unit United universal universe university unknown unless unlike unlikely until unusual up upon upper urban urge us use used useful user usual usually utility vacation valley valuable value variable variation variety various vary vast vegetable vehicle venture version versus very vessel veteran via victim victory video view viewer village violate violation violence violent virtually virtue virus visible vision visit visitor visual vital voice volume volunteer vote voter vs vulnerable wage wait wake walk wall wander want war warm warn warning wash waste watch water wave way we weak wealth wealthy weapon wear weather wedding week weekend weekly weigh weight welcome welfare well west western wet what whatever wheel when whenever where whereas whether which while whisper white who whole whom whose why wide widely widespread wife wild will willing win wind window wine wing winner winter wipe wire wisdom wise wish with withdraw within without witness woman wonder wonderful wood wooden word work worker working works workshop world worried worry worth would wound wrap write writer writing wrong yard yeah year yell yellow yes yesterday yet yield you young your yours yourself youth zone
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February Half-Blood Chronicle

As night hit the camp and the campers would return to their cabins they’d notice a stack of papers would be at the doorstep of their cabin. The language was default in Greek, making it easier for the demigods to read, but Spanish, English and Braille copies were available on request.

Camp Half-Blood Chronicle

May The Odds Ever Be In Your Favor

General News

Camp Half-Blood’s got Talent!

This month Su Jin Choi hosted a Talent Show for the campers, which had a decent turn out. Every camper tried their best so give them a big round of applause, won’t you?

Tearful Goodbyes

This month, we unfortunately had to see two campers that were beloved by many leave for greener pastures. Both Hailey Lovett and Andrew Vethos left for the Hunters of Artemis and England respectively. We wish both the best with their new lives wherever it may lead them.

Update: The Heind Chase

The judges have decided who the winners of the Heind chase and the winners are Deklyn Hayes, Tristan MacMillan, and Arthur Morse who had a brilliant plan to trick the deer with illusions. The runner ups are Alice Cinnamond, Flora Bandersen and Sebastian Constantine whose ambush almost went south if not for some quick thinking and sharp vines

Game 4: A Stable Job

Matching the pattern, next in order is the cleaning of the stables. Honestly….this one was the one I dreaded but my sister wanted a pony. Oh well! For this task, we have to clean mountains of shit while dealing with dangerous horses non-lethally. Real fun.

Game 5: Birdemic

The last Game of the Month is the Stymphalian Birds Relay Race! According to Lord Zeus, the remaining events will be based on the Olympic Games. This one is a one team race with a twist....you’re racing against flesh-eating birds. Fun. Let me watch from a safe distance because I’m going to go anywhere near those things, count me out.

Artemis’s Huntresses Welcomes a New Camper

Since time immemorial, Camp Half Blood has existed for one purpose: the training of demigods for the next generation. Chiron, our very activities director has trained many legendary heroes such as Jason of the Argonauts, Heracles, and Achillies. This last month, Camp Half-Blood can add another hero to the long rank of heroes it has trained: Hailey Lovett.
Lovett, a daughter of Circe, is and will always be a hero. Lovett, who had joined camp in January of 2034, almost a year and month later has left to join the Huntresses of Artemis. Huntresses of Artemis are a group of formidable female warriors, who have sworn an oath of maidenhood to be forever young and become maidenservents for the Goddess Artemis. Like their name suggests, these huntereresses travel the world to hunt down mythological monsters. Artemis and her Huntresses also supervised the third Olympic event, the capture of the Ceryneian Hind.
There are so few kids who are 14 and younger. I bet I could count these children on my two hands. It is no wonder that I would try to get close with other campers around my age. Hailey was no such exception. We essentially became best-friends. I made a drastic mistake however, the former counselor of Phobos, Blake Yang, told me to not hang out with Lovett, and I abandoned her. Lovett earlier had accused Yang of being a traitor as camp was embroiled in the Mycenaeans in a timeline that never was. Let the record forever show that I never listened to Lovett’s side of the story. It is something that I regret all my life.
Perhaps one of the reasons I am writing this is to atone for my mistakes. Yes, Hailey will most likely not return to camp, and even if she does, it is unlikely that she will look in the archives of old Camp Half-Blood archives to find this specific article. Yet, the least I could do is help her legacy at camp.
For those who participated in the battle of Manhattan during early fall, you would know it was very chaotic. Perhaps, you might have even seen campers turn on campers with seemingly no logical reason. Lovett’s mother, Circe, who was in her Mycenaean form at the time had manipulated Lovett into sowing discord into Camp Half Blood’s ranks in a way that only Eris would be proud of. I bring this up because some of you might still have lingering concerns of if Lovett was willingly working with Myceneans. Let me dispel all myths about this now: Lovett’s actions were out of her control.
I firmly believe that Hailey will be an amazing hunter. She is courageous at heart, she could create useful potions, and had a kindness that she was willing to show to some people. This is not to say that she was perfect, she had plenty of faults like any one of us. But for those that have any lingering worries, let those dissipate and fall to the wayside.
Everyone here at the Camp Half Blood Chronicle family wishes her good luck as Hailey begins her life as a Huntress. (Mackenzie Lee-Knoton)

Poseidon Poses Possible Problem For Alex Midkiff

On February 16th, Poseidon, lord of the sea hosted the 5th Olympic event, the fifth task of Hercules. Campers were forced to deal with dirty troublesome animals as they cleaned the Camp Halfblood stables that were filled with feces, food, and cobwebs. Armed with shovels, rakes, and implements of destruction, campers took to the task like moths to an open flame.
Though the task was stinky, for the most part, Poseidon and most campers were having a good time. Alex Midkiff, one of the few sons of Hecate present in camp must have been feeling most-resentful at Poseidon for the events that were undertaken by Odysseus and the Mycenaean version of Poseidon. While campers were grouping up, a Mare managed to sneak up behind Alex and bite him in the behind. (A picture showcasing the unfortunate event has been printed to the right of this article.) Alex, after using a quick healing spell and repair spell to undo the damage caused, proceeded to call Poseidon a discount Thanos, based on the antagonist from the immensely popular cult classic movie; Avengers: Infinity War. Let the chronicle now dispense some critically useful advice. NEVER anger a divine being, for they can smite you all the way into next month. At the time of this writing, Alex Midkiff has yet to be smited. (Mackenzie Lee-Knoton)

Music Review: Peter Paul and Mary

During the 1940s when the United States and the rest of the Allies were embroiled in a war against Germany, Italy, and Japan, America had experienced a revival of Folk Music. Performers such as Woody Gutherie, Pete Seeger and the Weavers had created a successful career for themselves.
Following the end of World of War Two, in the booming postwar economy of the 1950s, the Folk revival would soon reach its climax. Folk singers like Joan Baez and Bob Dylan would be listened to around the nation by college students on campuses and in coffee houses. Until the early 1960’s, when the British Invasion began, folk music would be all the rage. More folk bands would form.
Amongst the folk groups that formed, one particular stands out. In an obvious reference to biblical figures Peter Yarrow, Noel Paul, and Mary Travers would form a group in 1961 in New York City called Peter, Paul, and Mary. Despite the British Invasion that happened, Peter Paul and Mary would be immensely popular during this decade. The next year, in 1962, Peter, Paul, and Mary would release their first record Peter, Paul, and Mary which would include “500 Miles”, “Lemon Tree” and Pete Seeger classics like “Where have all the flowers gone?” For seven weeks, the album would be listed in the number one position of Billboard Magazine Top Ten and would go on to eventually sell two million copies.
“Puff the Magic Dragon” was released in 1963, a song about the loss of Childhood innocence based on a poem written by Lenny Lipton that Peter Yarrow put to music. The poem was inspired by both Peter Pan and another dragon poem by Ogden Nash.
Originally written by their friend John Denver, the group’s rendition of “Leaving on a Jet Plane” would go on to be the group’s only number one signle. The band broke up in 1970 for each member to work on their own career (and legal problems for Peter Yarrow, with a pardon by Jimmy Carter later). The band would rarely come together to host reunion concerts in the 1970s. During 1978, a summer reunion tour would be popular enough to get the band back together.
The band would due about 45 concerts a year, however in 2004, Mary Travers would be diagnosed with Leukemia. Unfortunately, following treatment, on September 16th 2009, Mary Travers at 72 would die following complications with her disease. It was also this year that the group would be inducted into Hit Parade’s Hall of Fame.
The group is characterized by soothing guitar accompanied by calming vocal lyrics. Mary Travers had such a wonderful peaceful singing voice. After a long day of training in the Arena or competing in the olympics, one could easily fall asleep after relaxing in bed. The group’s music often deals with powerful issues, hoping to change the world. “Leaving on a Jet Plane” for example is a song about a soldier saying goodbye to his girlfriend before he has to leave for Vietnam.
I would recommend this music group to almost anyone. (Mackenzie Lee-Knoton)

WHO MURDERED JESUS?

It was a sad night for the matchmaking. During the romantic evening, it was revealed that one person’s evening ended in death.
“It was a nightmare,” Coco smiled over a drink. “My type of fun.”
Coco, sarcastic wind nymph, was one of the suspects, among Rora, dryad and environmentalist, Lyn, flowery wolf lover, and Yal, a naiad. The halfbloods each could ask three questions to each to determine who the killer was.
As of publishing, no one has yet figured out who murdered Jesus. However, several halfbloods seem to be sniffing the right leads. Maybe soon this tragic event will be solved. (Jiana Mapleleaf)

Submissions

Ophelia’s Poems

"Mercury"

Listen up, to camp’s first halfblood track
A word filled gurgle, verbal attack
Who is the lucky one to hear my rhyme?
Listen up, y’all it’s Mercury time!
And what’s the real focus of this diss
Hurt some ponies, my God he was pissed
What an idiot, what a shame
Who’s to blame but himself?
Kicked him off the highest mountain
Shove him, shove him in a shelf
Where one stood a boy then there stood a flippin
Full of dissin, hear my spittin, Motherfudging Dolphin
A motherfudging dolphin
I bet that word just spoke for me
So go and boo-hoo at the slowest Mercury

“The Witch”

I am the witch of day’s end,
I weave the webs of the path’s I bend.
I breathe magic as easy as air
It fuels my soul, should I take care
The souls in the wind blow for I
As the trees bow, so does the sky.
I push and pull water, the ocean and sea
The rain is my friend, the wet’s my decree
The water below, lay dead and die
From driest of desert, to the tears I cry.
I let my hands roughen through earth and soil
The night is its rest, the day is my toil
The dust is truth, strength for the weak
And through all the lies, truth I shall seek
I roar in the sun, the light and the fire
My eyes are the flame and my feet are the pyre
The darkness, the smoke, the air, the light
My ashen remains, to see any sight
For I am the witch of day’s end
I weave the webs of the path’s I bend

Romantic Advice From The Matchmaker

Romance. It’s one of the most difficult things for anyone to cope with. One day, your relationship is fine, the next, you’re dumped for a nymph who is hotter then a daughter of Aphrodite. Not to be biased, but you halfblood females really have a lot of competition. Halfblood men too. Nymphs can be men as well. When you want to compete against literal nature goddesses for love, you have to play on their own turf. So, here is a list of five romantic nature places here at Camp Halfblood to take your beloved man, woman, or nonbinary halfblood too.

5 - A date by a waterfall

If you keep following the river upstream, you’re going to find a small lovely waterfall. This waterfall is a perfect place for a secret kiss. Most nymphs avoid it due to a… less than savory individual who resides there.
Nymphs, yes, this is Yal’s waterfall. Don’t inform them.

4 - A majestic rock

Okay, I know what you are thinking. A rock, how boring? This isn’t just any rock. About a mile out from what you halfbloods call Zeus’ Fist stupid name, resides a beautiful blue rock, known as Wind Rock. When the wind hits it right, it sings. Yes, sings. It’s amazing.
Coco, I give you full permission to do your thing.

3 - Wolf’s Cave

This sight is tucked in between the Stables and Wind Rock. It’s a cave that looks exactly like a wolf’s mouth. The most private and beautiful of spots. There is a reason that flower nymphs enjoy this place.
yes, Lyn is a flower nymph. Guys, we have to stick together. No alienating anyone.

2 - The Clearing

You’ve never seen beauty until you have seen this. A clearing in the middle, with a single maple tree. At night, it is filled with fireflies.
Sorry Rora

1 - The Sapling Site

Have you and your loved one talked about having a kid? No need, just come to this place, and you can help a baby nymph have a home by planting trees. Not only is it a beautiful forest, it’s also a beautiful date!
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